research data . Dataset . 2018

Mirna Gene Regulatory Networks For 38 Human Tissues

Kuijjer, Marieke Lydia; Quackenbush, John; Glass, Kimberly;
Open Access
  • Published: 19 Jul 2018
  • Publisher: Zenodo
Abstract
We reconstructed miRNA regulatory networks for 38 tissues from the Genotype-Tissue Expression project (GTEx) using two different prior networks, one obtained with target predictions from TargetScan and one with target predictions from miRanda. We used these networks to investigate gene expression and regulation by miRNAs across these tissues. In the RData file, we share the following objects: - exp: a 16,161 by 9,435 data frame including normalized expression data for each sample. - expTS: a 16,161 by 38 matrix including the tissue-specificity scores for each gene in each tissue. - netT: a 10,391,523 by 41 data frame that includes the miRNA regulatory networks. ...
Subjects
free text keywords: networks, gene regulatory networks, miRNA regulatory networks, gene regulation, miRNA, PUMA, PUMA networks
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