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The Process Of Hdac11 Assay Development: Check For Linearity And Km-Repeat

Research datakeyboard_double_arrow_right Dataset 03 Jul 2018Publisher:Zenodo

Authors: Abbey, Megha; Vedadi, Masoud;

doi: 10.5281/zenodo.1304365 , 10.5281/zenodo.1304364

The Process Of Hdac11 Assay Development: Check For Linearity And Km-Repeat

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Abstract

The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.

The linearity for HDAC11 activity for Boc-Lys-(TFA)-AMC substrate was monitored using the newly optimized buffer conditions. This was followed upon by Km calculation.

Related Organizations

University of Toronto
Canada

Keywords

boc-lys-TFA, enzyme kinetics, HDAC11, histone deacetylase, enzyme linearity, histone deacetylase 11, Km

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