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Quantification of E-cadherin Expression in H1299 NSD3 Knockdown Cells

Research datakeyboard_double_arrow_right Dataset 23 May 2018Publisher:Zenodo

Authors: Dilworth, David; Barsyte-Lovejoy, Dalia;

doi: 10.5281/zenodo.1263398 , 10.5281/zenodo.1251838 , 10.5281/zenodo.1251839

Quantification of E-cadherin Expression in H1299 NSD3 Knockdown Cells

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Abstract

Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.

SGC Open Notebook Project to Characterize the HMTase NSD3 Exp023 Objective: Having observed downregulation of E-cadherin protein levels in response to NSD3 overexpression in H1299 cells (exp021), I was next interested in testing the consequences of NSD3 knockdown. To do so, I transfected H1299 cells with siRNA targeting NSD3, both short and long isoforms, and assayed E-cadherin expression by western blotting.

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