Salt is essential for growth at certain limits, but life dwelling in harsh, salty environments are the halophiles. Studies on the halophilic bacteria, archaea, and fungi are reported around different locations, but the fungus Aspergillus species is a predominant halophilic eukaryote reported in various research works. They have been reported from an environment with high salt concentrations. Halophilic Aspergillus species grow better in harsh conditions and have an exciting opportunity for research and application ahead of them. Their potential in biotechnology, together with their special capacity for adaptation to harsh settings, makes them precious in many sectors from environmental science, to biotechnology, and even in bioremediation settings. Therefore, this work review the physiology and unique adaptations of halophilic Aspergillus species in extreme environments, biomolecule produces and their applications in different areas and future prospects.