Project_01 Q25 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the basal lateral amygdala (BLA) on development, and, on expression
Project_01 Q25 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the basal lateral amygdala (BLA) on development, and, on expression
This study (Q25) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q25 was Project_01 entitled: "Probing the neural circuit mediating sensitization and compulsive checking". This project had two separate studies, designated as Q25Bla1 and Q25Bla2. The title of study Q25Bla1 was "Probing the neural circuit mediating sensitization and compulsive checking: role of the basal lateral amygdala (BLA) on development" and the title of study Q25Bla2 was "Probing the neural circuit mediating sensitization and compulsive checking: role of the basal lateral amygdala (BLA) on expression". Title of experiment in Q25Bla1 was "Effect of an NMDA lesion of the BLA on the development of sensitization and compulsive checking" and title of experiment in Q25Bla2 was "Effect of an NMDA lesion of the BLA on the expression of sensitization and compulsive checking". For the development study (Q25Bla1), rats received a lesion targeted at the BLA and the effect of this lesion on the induction of compulsive checking in our standard paradigm was measured. For the expression study (Q25Bla2), rats received our standard treatment to induce compulsive checking and then received a lesion targeted at the BLA and the effect of this lesion on the expression of compulsive checking was measured. This dataset has the same Design and Procedure as dataset deposits for StudyID Q26 doi:10.20383/102.0438 and StudyID Q28 doi:10.20383/102.0436
Psychology and cognitive sciences, compulsive checking behavior, dopamine receptor agonist, lesion effect on expression of established behavior, Psychology, social and behavioural aspects, exploration, large testing environment 160x160 cm, Basic medicine and life sciences, obsessive compulsive disorder, trials available 1562, Behavioural neuroscience of reward and motivation, chronic treatment with quinpirole (0.5 mg/kg), Neurosciences, medical and health and physiological aspects, not elsewhere classified, open field, plot of routes of locomotion, Cognitive behaviour, Neurosciences, biological and chemical aspects, OCD, Neurosciences comportementales de la récompense et de la motivation, Psychopathology, motor activity, animal model, male rats Long-Evans, Neurosciences, aspects médicaux, physiologiques, et de la santé, non classé ailleurs, behavioral sensitization, digitized track record, repeated testing, locomotion, Biological sciences, basal lateral amygdala (BLA) NMDA lesion, repeated injections of saline vehicle, Cognitive sciences, Psychopathologie, security motivation system, Comportement cognitif, video recording, number of rats 112, repeated trials per rat 14, Neurosciences, medical and physiological and health aspects, lesion effect on development of response to repeated treatment
Psychology and cognitive sciences, compulsive checking behavior, dopamine receptor agonist, lesion effect on expression of established behavior, Psychology, social and behavioural aspects, exploration, large testing environment 160x160 cm, Basic medicine and life sciences, obsessive compulsive disorder, trials available 1562, Behavioural neuroscience of reward and motivation, chronic treatment with quinpirole (0.5 mg/kg), Neurosciences, medical and health and physiological aspects, not elsewhere classified, open field, plot of routes of locomotion, Cognitive behaviour, Neurosciences, biological and chemical aspects, OCD, Neurosciences comportementales de la récompense et de la motivation, Psychopathology, motor activity, animal model, male rats Long-Evans, Neurosciences, aspects médicaux, physiologiques, et de la santé, non classé ailleurs, behavioral sensitization, digitized track record, repeated testing, locomotion, Biological sciences, basal lateral amygdala (BLA) NMDA lesion, repeated injections of saline vehicle, Cognitive sciences, Psychopathologie, security motivation system, Comportement cognitif, video recording, number of rats 112, repeated trials per rat 14, Neurosciences, medical and physiological and health aspects, lesion effect on development of response to repeated treatment
79. OBSESSIVE-COMPULSIVE DISORDER AS A DYSFUNCTION OF SECURITY MOTIVATION. Hinds, A.; Szechtman, H.; Van Ameringen, M.; Mancini, C. Dept. Psychiatry & Behav Neurosc, McMaster Univ, Hamilton, ON; Schmidt, L. Dept Psychology, Behavior & Neuroscience, McMaster Univ; Woody, E. Dept. Psychol., Univ Waterloo, Waterloo, ON, Canada. A recent theory (Szechtman & Woody, Psychol Review, 111:111-127, 2004) posits a Security Motivation System (SMS) activated by potential, rather than by imminent, threat to the individual. The SMS coordinates motor activity that probes the environment for danger and includes precaution behaviors such as checking (eg, for the presence of predators) and cleaning (for infestation by germs, etc), and induces also an
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Volume 46, Issue 3, Pages 257-261
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