ROS-Specific Huntingtin Interactions: Chromatin retention assay with huntingtin fragments containing PBM3

Dataset OPEN
Maiuri, Tamara; Truant, Ray;
(2019)
  • Publisher: Figshare
  • Identifiers: doi: 10.5281/zenodo.3459659, doi: 10.5281/zenodo.3459660
  • Subject: Molecular Biology | chromatin retention assay | Neuroscience | poly ADP ribose | Medicine | Cell Biology | Genetics | huntingtin | Huntington's disease | ROS | reactive oxygen species | Biochemistry | oxidative stress
    • FOR: 111714 Mental Health | 39999 Chemical Sciences not elsewhere classified
    mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalities | mental disorders | nervous system diseases | nervous system

<p>Huntingtin amino acids 1790-1798 make up a potential PAR binding motif (PBM3). Two huntingtin fragments (1208-1810 and 1775-2413) were tested for chromatin retention upon oxidative stress.</p>
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