research data . Dataset . 2016

Bile Salts Modulate the Mucin-Activated Type VI Secretion System of Pandemic Vibrio cholerae

Bachmann, Verena; Kostiuk, Benjamin; Unterweger, Daniel; Diaz-Satizabal, Laura; Ogg, Stephen; Pukatzki, Stefan;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>The causative agent of cholera, <i>Vibrio cholerae</i>, regulates its diverse virulence factors to thrive in the human small intestine and environmental reservoirs. Among this pathogen’s arsenal of virulence factors is the tightly regulated type VI secretion system (T6SS). This system acts as an inverted bacteriophage to inject toxins into competing bacteria and eukaryotic phagocytes. <i>V</i>. <i>cholerae</i> strains responsible for the current 7<sup>th</sup> pandemic activate their T6SS within the host. We established that T6SS-mediated competition occurs upon T6SS activation in the infant mouse, and that this system is functional under anaerobic condi...
Subjects
free text keywords: Uncategorised, T 6SS, commensal bacteria, type VI secretion system, T 6SS bile acids, T 6SS competition, Virulence factors, Bile Salts Modulate, host factors mucins, cholerae T 6SS, T 6SS activation, Pandemic Vibrio cholerae, T 6SS activity
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Dataset . 2016
Provider: figshare
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