research data . Dataset . 2017

HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study

J. Henrich, Timothy; Hatano, Hiroyu; Bacon, Oliver; Hogan, Louise E.; Rutishauser, Rachel; Hill, Alison; F. Kearney, Mary; M. Anderson, Elizabeth; P. Buchbinder, Susan; Cohen, Stephanie E.; ...
  • Published: 01 Jan 2017
  • Publisher: Figshare
Abstract
<div><p>Background</p><p>It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited from a pre-exposure prophylaxis (PrEP) program who started prophylactic ART an estimated 10 days (Participant A; 54-year-old male) and 12 days (Participant B; 31-year-old male) after infection with peak plasma HIV RNA of 220 copies/mL and 3,343 copies/mL, respectively. Extensive testing of blood and tissue for HIV persistence was performed, and PrEP Participant A underwent analytical treatment interruption (ATI) following 32 weeks of continuous ART.</p><p>Methods...
Subjects
free text keywords: Medicine, Biotechnology, Immunology, Cancer, 110309 Infectious Diseases, 60506 Virology, Computational Biology, report HIV relapse, HIV persistence, peak plasma HIV RNA, bone marrow, tumor marker CD 30, antiretroviral therapy, CSF, Rebound plasma HIV sequences, ATI, ART-free HIV remission, PBMC, DNA, culture-based detection methods, humanized mouse outgrowth assay, 4- drug ART intensification, ART-free remission, lymph node tissues, PrEP Participant B, hyperacute infection, HIV RNA, PrEP Participant
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Dataset . 2017
Provider: figshare
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