Metabolic Reprogramming for Producing Energy and Reducing Power in Fumarate Hydratase Null Cells from Hereditary Leiomyomatosis Renal Cell Carcinoma

Yang, Youfeng; Lane, Andrew N.; J. Ricketts, Christopher; Sourbier, Carole; Wei, Ming-Hui; Shuch, Brian; Pike, Lisa; Wu, Min; A. Rouault, Tracey; G. Boros, Laszlo; W.-M. Fan, Teresa; Linehan, W. Marston;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0072179
  • Subject: Biological Sciences | Reprogramming | producing | reducing | fumarate | hydratase | | cells | hereditary | leiomyomatosis | renal

<div><p>Fumarate hydratase (FH)-deficient kidney cancer undergoes metabolic remodeling, with changes in mitochondrial respiration, glucose, and glutamine metabolism. These changes represent multiple biochemical adaptations in glucose and fatty acid metabolism that suppo... View more
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