research data . Dataset . 2018

Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice

Federico, Lorenzo; Yang, Liping; Brandon, Jason; Panchatcharam, Manikandan; Ren, Hongmei; Mueller, Paul; Sunkara, Manjula; Escalante-Alcalde, Diana; Morris, Andrew J.; S. Smyth, Susan;
  • Published: 01 Jan 2018
  • Publisher: Figshare
Abstract
<div><p>Dephosphorylation of phosphatidic acid (PA) is the penultimate step in triglyceride synthesis. Adipocytes express soluble intracellular PA-specific phosphatases (Lipins) and broader specificity membrane-associated lipid phosphate phosphatases (LPPs) that can also dephosphorylate PA. Inactivation of lipin1 causes lipodystrophy in mice due to defective developmental adipogenesis. Triglyceride synthesis is diminished but not ablated by inactivation of lipin1 in differentiated adipocytes implicating other PA phosphatases in this process. To investigate the possible role of LPPs in adipocyte lipid metabolism and signaling we made mice with adipocyte-targeted ...
Subjects
free text keywords: Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Developmental Biology, Computational Biology, adipocyte sphingolipid synthesis, diet-dependent sphingolipid synthesis, diet-induced adipose tissue expansion, adipocyte lipid metabolism, lipid phosphatase activity, LPP 3, LPP 3 substrate sphingosine 1- phosphate, serine palmitoyl transferase, intracellular PA-specific phosphatases, specificity membrane-associated lipid phosphate phosphatases, LPP 3 deficiency, Adipocyte LPP 3 deficiency, lipin 1 causes lipodystrophy, Lipid phosphate phosphatase 3, adipocyte LPP 3 deficiency, Western diet-fed mice, 69999 Biological Sciences not elsewhere classified, 39999 Chemical Sciences not elsewhere classified
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Dataset . 2018
Provider: figshare
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