research data . Dataset . 2016

Noisy Galvanic Vestibular Stimulation Promotes GABA Release in the Substantia Nigra and Improves Locomotion in Hemiparkinsonian Rats

Samoudi, Ghazaleh; Nissbrandt, Hans; B. Dutia, Mayank; Bergquist, Filip;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><h3>Background</h3><p>The vestibular system is connected to spinal, cerebellar and cerebral motor control structures and can be selectively activated with external electrodes. The resulting sensation of disturbed balance can be avoided by using stochastic stimulation patterns. Adding noise to the nervous system sometimes improves function. Small clinical trials suggest that stochastic vestibular stimulation (SVS) may improve symptoms in Parkinson's disease. We have investigated this claim and possible mechanisms using the 6-hydroxydopamine (6-OHDA) hemilesion model of Parkinson's disease.</p> <h3>Methodology/Principal Findings</h3><p>Animals were tested in ...
Subjects
Medical Subject Headings: nervous system
free text keywords: Neuroscience, Physiology, noisy, galvanic, vestibular, stimulation, promotes, gaba, substantia, nigra, improves, locomotion, hemiparkinsonian, rats
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Dataset . 2016
Provider: figshare
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