research data . Dataset . 2016

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

W. J. Unger, Wendy; Pearson, Todd; R. F. Abreu, Joana; Laban, Sandra; R. van der Slik, Arno; Mulder-van der Kracht, Sacha; G. D. Kester, Michel; V. Serreze, Dave; D. Shultz, Leonard; Griffioen, Marieke; ...
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Despite increasing evidence that autoreactive CD8 T-cells are involved in both the initiation of type 1 diabetes (T1D) and the destruction of beta-cells, direct evidence for their destructive role <em>in-vivo</em> is lacking. To address a destructive role for autoreactive CD8 T-cells in human disease, we assessed the pathogenicity of a CD8 T-cell clone derived from a T1D donor and specific for an HLA-A2-restricted epitope of islet-specific glucose-6-phosphatase catalytic-subunit related protein (IGRP). HLA-A2/IGRP tetramer staining revealed a higher frequency of IGRP-specific CD8 T-cells in the peripheral blood of recent onset human individuals than of h...
Subjects
Medical Subject Headings: endocrine system
free text keywords: Cell Biology, Physiology, Chemistry, Immunology, islet-specific, ctl, cloned, beta-cell, engraftment, hla-a2, transgenic, , mice
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Dataset . 2016
Provider: figshare
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