research data . Dataset . 2016

Concordant Signaling Pathways Produced by Pesticide Exposure in Mice Correspond to Pathways Identified in Human Parkinson's Disease

Gollamudi, Seema; Johri, Ashu; Y. Calingasan, Noel; Yang, Lichuan; Elemento, Olivier; Flint Beal, M.;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Parkinson's disease (PD) is a neurodegenerative disease in which the etiology of 90 percent of the patients is unknown. Pesticide exposure is a major risk factor for PD, and paraquat (PQ), pyridaben (PY) and maneb (MN) are amongst the most widely used pesticides. We studied mRNA expression using transcriptome sequencing (RNA-Seq) in the ventral midbrain (VMB) and striatum (STR) of PQ, PY and paraquat+maneb (MNPQ) treated mice, followed by pathway analysis. We found concordance of signaling pathways between the three pesticide models in both the VMB and STR as well as concordance in these two brain areas. The concordant signaling pathways with relevance t...
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free text keywords: Genetics, Neuroscience, Biological Sciences, concordant, signaling, pathways, produced, pesticide, mice, correspond, identified
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Dataset . 2016
Provider: figshare
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