research data . Dataset . 2016

Functional Maps of Protein Complexes from Quantitative Genetic Interaction Data

Bandyopadhyay, Sourav; Kelley, Ryan; Krogan, Nevan J.; Ideker, Trey;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Recently, a number of advanced screening technologies have allowed for the comprehensive quantification of aggravating and alleviating genetic interactions among gene pairs. In parallel, TAP-MS studies (tandem affinity purification followed by mass spectroscopy) have been successful at identifying physical protein interactions that can indicate proteins participating in the same molecular complex. Here, we propose a method for the joint learning of protein complexes and their functional relationships by integration of quantitative genetic interactions and TAP-MS data. Using 3 independent benchmark datasets, we demonstrate that this method is >50% more ac...
Subjects
free text keywords: Medicine, Genetics, maps, complexes, quantitative
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Dataset . 2016
Provider: figshare
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