research data . Dataset . 2016

Metabolic Regulation in Progression to Autoimmune Diabetes

Sysi-Aho, Marko; Ermolov, Andrey; V. Gopalacharyulu, Peddinti; Tripathi, Abhishek; Seppänen-Laakso, Tuulikki; Maukonen, Johanna; Mattila, Ismo; T. Ruohonen, Suvi; Vähätalo, Laura; Yetukuri, Laxman; ...
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Recent evidence from serum metabolomics indicates that specific metabolic disturbances precede β-cell autoimmunity in humans and can be used to identify those children who subsequently progress to type 1 diabetes. The mechanisms behind these disturbances are unknown. Here we show the specificity of the pre-autoimmune metabolic changes, as indicated by their conservation in a murine model of type 1 diabetes. We performed a study in non-obese prediabetic (NOD) mice which recapitulated the design of the human study and derived the metabolic states from longitudinal lipidomics data. We show that female NOD mice who later progress to autoimmune diabetes exhib...
Subjects
free text keywords: Immunology, Biological Sciences, metabolic, progression, autoimmune
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Dataset . 2016
Provider: figshare
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