MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia

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Pikman, Yana ; H Lee, Benjamin ; Mercher, Thomas ; McDowell, Elizabeth ; L Ebert, Benjamin ; Gozo, Maricel ; Cuker, Adam ; Wernig, Gerlinde ; Moore, Sandra ; Galinsky, Ilene ; J DeAngelo, Daniel ; J Clark, Jennifer ; J Lee, Stephanie ; R Golub, Todd ; Wadleigh, Martha ; Gary Gilliland, D. ; L Levine, Ross
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pmed.0030270
  • Subject: Genetics | Cancer | Hematology | somatic | activating | mutation | myelofibrosis | myeloid

<div><h3>Background</h3><p>The <em>JAK2V617F</em> allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid metaplasia (MF). Subsequent analysis has shown that constitutive activation of th... View more
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