research data . Dataset . 2016

Dkk1 Regulates Ventral Midbrain Dopaminergic Differentiation and Morphogenesis

Ribeiro, Diogo; Ellwanger, Kristina; Glagow, Désirée; Theofilopoulos, Spyridon; S. Corsini, Nina; Martin-Villalba, Ana; Niehrs, Christof; Arenas, Ernest;
  • Published: 01 Jan 2016
  • Publisher: Figshare
<div><p>Dickkopf1 (Dkk1) is a Wnt/β-catenin inhibitor that participates in many processes during embryonic development. One of its roles during embryogenesis is to induce head formation, since <em>Dkk1</em>-null mice lack head structures anterior to midbrain. The Wnt/β-catenin pathway is also known to regulate different aspects of ventral midbrain (VM) dopaminergic (DA) neuron development and, <em>in vitro</em>, Dkk1-mediated inhibition of the Wnt/β-catenin pathway improves the DA differentiation in mouse embryonic stem cells (mESC). However, the <em>in vivo</em> function of Dkk1 on the development of midbrain DA neurons remains to be elucidated. Here we examine...
Medical Subject Headings: musculoskeletal diseasesnervous system
free text keywords: Neuroscience, Developmental Biology, dkk1, regulates, ventral, midbrain, dopaminergic, differentiation, morphogenesis
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Dataset . 2016
Provider: figshare
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