research data . Dataset . 2016

Toxoplasma Effector MAF1 Mediates Recruitment of Host Mitochondria and Impacts the Host Response

Pernas, Lena; Adomako-Ankomah, Yaw; J. Shastri, Anjali; E. Ewald, Sarah; Treeck, Moritz; P. Boyle, Jon; Boothroyd, John C.;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Recent information has revealed the functional diversity and importance of mitochondria in many cellular processes including orchestrating the innate immune response. Intriguingly, several infectious agents, such as <i>Toxoplasma</i>, <i>Legionella</i>, and <i>Chlamydia</i>, have been reported to grow within vacuoles surrounded by host mitochondria. Although many hypotheses have been proposed for the existence of host mitochondrial association (HMA), the causes and biological consequences of HMA have remained unanswered. Here we show that HMA is present in type I and III strains of <i>Toxoplasma</i> but missing in type II strains, both <i>in vitro</i> an...
Subjects
free text keywords: Biological Sciences, cell biology, Molecular cell biology, Evolutionary biology, genetics, immunology, microbiology, Model organisms, effector, maf1, mediates, recruitment, mitochondria, impacts
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Dataset . 2016
Provider: figshare
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