research data . Dataset . 2016

Factors Associated with Worse Lung Function in Cystic Fibrosis Patients with Persistent Staphylococcus aureus

Junge, Sibylle; Görlich, Dennis; Reijer, Martijn den; Wiedemann, Bärbel; Tümmler, Burkhard; Ellemunter, Helmut; Dübbers, Angelika; Küster, Peter; Ballmann, Manfred; Koerner-Rettberg, Cordula; ...
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Background</p><p><i>Staphylococcus aureus</i> is an important pathogen in cystic fibrosis (CF). However, it is not clear which factors are associated with worse lung function in patients with persistent <i>S</i>. <i>aureus</i> airway cultures. Our main hypothesis was that patients with high <i>S</i>. <i>aureus</i> density in their respiratory specimens would more likely experience worsening of their lung disease than patients with low bacterial loads.</p><p>Methods</p><p>Therefore, we conducted an observational prospective longitudinal multi-center study and assessed the association between lung function and <i>S</i>. <i>aureus</i> bacterial density in r...
Subjects
free text keywords: Biochemistry, Medicine, Microbiology, Cell Biology, Immunology, Cancer, 110309 Infectious Diseases, 60506 Virology, IL -6 levels, lung function, Results 195 patients, Cystic Fibrosis Patients, SCV, aureus virulence factors, Persistent Staphylococcus aureus Background Staphylococcus aureus, aureus airway cultures, aureus small-colony variants, lung function decline, co-infection, CF, aureus density, NCT
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Dataset . 2016
Provider: figshare
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