Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival

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Hörnberg, Emma; Bovinder Ylitalo, Erik; Crnalic, Sead; Antti, Henrik; Stattin, Pär; Widmark, Anders; Bergh, Anders; Wikström, Pernilla;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0019059
  • Subject: Molecular Biology | metastases | androgen | receptor | splice | cancer | prostate | variants | castration-resistance
    mesheuropmc: urologic and male genital diseases

<div><h3>Background</h3><p>Constitutively active androgen receptor variants (AR-V) lacking the ligand binding domain (LBD) may promote the development of castration-resistant prostate cancer (CRPC). The expression of AR-Vs in the clinically most important metastatic sit... View more
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