research data . Dataset . 2016

Quantitative Susceptibility Mapping Indicates a Disturbed Brain Iron Homeostasis in Neuromyelitis Optica – A Pilot Study

Doring, Thomas Martin; Granado, Vanessa; Rueda, Fernanda; Deistung, Andreas; Reichenbach, Juergen R.; Tukamoto, Gustavo; Gasparetto, Emerson Leandro; Schweser, Ferdinand;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Dysregulation of brain iron homeostasis is a hallmark of many neurodegenerative diseases and can be associated with oxidative stress. The objective of this study was to investigate brain iron in patients with Neuromyelitis Optica (NMO) using quantitative susceptibility mapping (QSM), a quantitative iron-sensitive MRI technique. 12 clinically confirmed NMO patients (6 female and 6 male; age 35.4y±14.2y) and 12 age- and sex-matched healthy controls (7 female and 5 male; age 33.9±11.3y) underwent MRI of the brain at 3 Tesla. Quantitative maps of the effective transverse relaxation rate (R<sub>2</sub>*) and magnetic susceptibility were calculated and a blind...
Subjects
free text keywords: Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Developmental Biology, Cancer, Science Policy, 69999 Biological Sciences not elsewhere classified, 39999 Chemical Sciences not elsewhere classified, ROI-based group comparison analysis, relaxation rate, Disturbed Brain Iron Homeostasis, brain iron, Decreased relaxation, -22 ppb, Neuromyelitis Optica, R 2, Quantitative maps, 12 patients, iron-sensitive MRI technique, chemical redistribution, Pilot Study Dysregulation, neurodegenerative diseases, Quantitative Susceptibility Mapping Indicates, ANCOVA-like analysis, 3 Tesla, reference region, 12 age, brain iron homeostasis, brain iron concentration, oxidative stress, NMO, QSM, Magnetic susceptibility values, radiation, nucleus, susceptibility mapping
Communities
Science and Innovation Policy Studies
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Dataset . 2016
Provider: figshare
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