research data . Dataset . 2016

Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model

Alvarez-Fischer, Daniel; Noelker, Carmen; Vulinović, Franca; Grünewald, Anne; Chevarin, Caroline; Klein, Christine; H. Oertel, Wolfgang; Hirsch, Etienne C.; P. Michel, Patrick; Hartmann, Andreas;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that bilateral acupoint stimulation of lower hind limbs with bee venom was protective in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. In particular, a specific component of bee venom, apamin, has previously been shown to have protective effects on dopaminergic neurons <i>in vitro</i>. However, no information regarding a potential protective action of apamin in animal models of PD is available to date. The specific goals of the present study were to (i) establish that the pro...
Subjects
Medical Subject Headings: complex mixturesfungi
free text keywords: Medicine, Biological Sciences, immunology, Immunologic techniques, Immunohistochemical analysis, Model organisms, Animal models, mouse, neuroscience, Cellular neuroscience, ion channels, Neurochemistry, Neurochemicals, dopamine, neurology, Neurodegenerative diseases, Parkinson disease, venom, apamin, neuroprotective, agents, parkinson
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Dataset . 2016
Provider: figshare
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