research data . Dataset . 2016

Evaluating Genome-Wide Association Study-Identified Breast Cancer Risk Variants in African-American Women

Long, Jirong; Zhang, Ben; B. Signorello, Lisa; Cai, Qiuyin; Deming-Halverson, Sandra; J. Shrubsole, Martha; Sanderson, Maureen; Dennis, Joe; Michailiou, Kyriaki; F. Easton, Douglas; ...
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Genome-wide association studies (GWAS), conducted mostly in European or Asian descendants, have identified approximately 67 genetic susceptibility loci for breast cancer. Given the large differences in genetic architecture between the African-ancestry genome and genomes of Asians and Europeans, it is important to investigate these loci in African-ancestry populations. We evaluated index SNPs in all 67 breast cancer susceptibility loci identified to date in our study including up to 3,300 African-American women (1,231 cases and 2,069 controls), recruited in the Southern Community Cohort Study (SCCS) and the Nashville Breast Health Study (NBHS). Seven SNPs...
Subjects
free text keywords: Medicine, Biological Sciences, Computational biology, genomics, Genome analysis tools, Genome-wide association studies, genetics, Human genetics, Cancer genetics, epidemiology, Cancer epidemiology, Obstetrics and gynecology, breast cancer, oncology, Cancer risk factors, Genetic causes of cancer, Cancers and neoplasms, Breast tumors, genome-wide, study-identified, cancer, variants, african-american
Download from
figshare
Dataset . 2016
Provider: figshare
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue