research data . Dataset . 2016

Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1

Ge, Xianpeng; Ritter, Susan Y.; Tsang, Kelly; Shi, Ruirui; Takei, Kohtaro; O. Aliprantis, Antonios;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Cartilage acidic protein 1 (CRTAC1) was recently identified as an elevated protein in the synovial fluid of patients with osteoarthritis (OA) by a proteomic analysis. This gene is also upregulated in both human and mouse OA by transcriptomic analysis. The objective of this study was to characterize the expression and function of CRTAC1 in OA. Here, we first confirm the increase of CRTAC1 in cartilage biopsies from OA patients undergoing joint replacement by real-time PCR and immunohistochemistry. Furthermore, we report that proinflammatory cytokines interleukin-1beta and tumor necrosis factor alpha upregulate CRTAC1 expression in primary human articular ...
Subjects
free text keywords: Biochemistry, Microbiology, Cell Biology, Physiology, Pharmacology, Ecology, Immunology, Developmental Biology, Science Policy, 69999 Biological Sciences not elsewhere classified, synovial fibroblasts, OA, PCR, DMM, proinflammatory cytokines interleukin -1beta, upregulate CRTAC 1 expression, tumor necrosis factor, Protein 1 Cartilage acidic protein 1, CRTAC 1
Communities
Science and Innovation Policy Studies
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Dataset . 2016
Provider: figshare
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