research data . Dataset . 2016

Regenerative Capacity of Old Muscle Stem Cells Declines without Significant Accumulation of DNA Damage

Cousin, Wendy; Liane Ho, Michelle; Desai, Rajiv; Tham, Andrea; Yuzen Chen, Robert; Kung, Sunny; Elabd, Christian; M. Conboy, Irina;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>The performance of adult stem cells is crucial for tissue homeostasis but their regenerative capacity declines with age, leading to failure of multiple organs. In skeletal muscle this failure is manifested by the loss of functional tissue, the accumulation of fibrosis, and reduced satellite cell-mediated myogenesis in response to injury. While recent studies have shown that changes in the composition of the satellite cell niche are at least in part responsible for the impaired function observed with aging, little is known about the effects of aging on the intrinsic properties of satellite cells. For instance, their ability to repair DNA damage and the ef...
Subjects
free text keywords: Biological Sciences, Anatomy and physiology, Musculoskeletal system, muscle, Physiological processes, aging, Biochemistry, Nucleic acids, dna, DNA repair, proteins, DNA-binding proteins, biophysics, Model organisms, Animal models, mouse, Molecular cell biology, Cellular types, Muscle fibers, Muscle cells, cells, declines, accumulation
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Dataset . 2016
Provider: figshare
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