research data . Dataset . 2016

TGF-b2 Induction Regulates Invasiveness of Theileria-Transformed Leukocytes and Disease Susceptibility

Chaussepied, Marie; Janski, Natacha; Baumgartner, Martin; Lizundia, Regina; Jensen, Kirsty; Weir, William; R. Shiels, Brian; B. Weitzman, Jonathan; J. Glass, Elizabeth; Werling, Dirk; ...
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p><em>Theileria</em> parasites invade and transform bovine leukocytes causing either East Coast fever (<em>T. parva</em>), or tropical theileriosis (<em>T. annulata</em>). Susceptible animals usually die within weeks of infection, but indigenous infected cattle show markedly reduced pathology, suggesting that host genetic factors may cause disease susceptibility. Attenuated live vaccines are widely used to control tropical theileriosis and attenuation is associated with reduced invasiveness of infected macrophages <em>in vitro</em>. Disease pathogenesis is therefore linked to aggressive invasiveness, rather than uncontrolled proliferation of <em>Theileria<...
Subjects
free text keywords: Physics, Cell Biology, tgf-b2, induction, regulates, invasiveness, leukocytes, susceptibility
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Dataset . 2016
Provider: figshare
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