A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity

D. J. Dicks, Matthew; J. Spencer, Alexandra; J. Edwards, Nick; Wadell, Göran; Bojang, Kalifa; C. Gilbert, Sarah; V. S. Hill, Adrian; G. Cottingham, Matthew;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0040385
  • Subject: Immunology | chimpanzee | adenovirus | vector | systems | derivation | comparative | immunogenicity

<div><p>Recombinant adenoviruses are among the most promising tools for vaccine antigen delivery. Recently, the development of new vectors has focused on serotypes to which the human population is less exposed in order to circumvent pre-existing anti vector immunity. Th... View more
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