Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

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V. S. Varma, Manthena ; Obach, R. Scott ; Rotter, Charles ; Miller, Howard R. ; Chang, George ; Steyn, Stefanus J. ; El-Kattan, Ayman ; Troutman, Matthew D.
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/jm901371v.s001
  • Subject: Biophysics | Biochemistry | Medicine | Pharmacology | Biotechnology | Hematology | physicochemical space | trend | analysis | RB | Fa | fraction | Fg | Fh | Human Intestinal Absorption | Optimum Oral Bioavailability | physicochemical properties influence bioavailability | elimination | MW
    • FOR: 39999 Chemical Sciences not elsewhere classified

Oral bioavailability (<i>F</i>) is a product of fraction absorbed (Fa), fraction escaping gut-wall elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a database comprised of Fa, Fg, Fh, and <i>F</i> values for 309 drugs in humans, an ... View more
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