research data . Dataset . 2016

Resveratrol Treatment Reduces Cardiac Progenitor Cell Dysfunction and Prevents Morpho-Functional Ventricular Remodeling in Type-1 Diabetic Rats

Delucchi, Francesca; Berni, Roberta; Frati, Caterina; Cavalli, Stefano; Graiani, Gallia; Sala, Roberto; Chaponnier, Christine; Gabbiani, Giulio; Calani, Luca; Rio, Daniele Del; ...
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Emerging evidence suggests that both adult cardiac cell and the cardiac stem/progenitor cell (CSPC) compartments are involved in the patho-physiology of diabetic cardiomyopathy (DCM). We evaluated whether early administration of Resveratrol, a natural antioxidant polyphenolic compound, in addition to improving cardiomyocyte function, exerts a protective role on (i) the progenitor cell pool, and (ii) the myocardial environment and its impact on CSPCs, positively interfering with the onset of DCM phenotype. Adult Wistar rats (n = 128) with streptozotocin-induced type-1 diabetes were either untreated (D group; n = 54) or subjected to administration of trans...
Subjects
Medical Subject Headings: cardiovascular system
free text keywords: Biochemistry, Cell Biology, Physiology, Chemistry, resveratrol, reduces, cardiac, progenitor, dysfunction, prevents, morpho-functional, ventricular, remodeling, type-1, diabetic, rats
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Dataset . 2016
Provider: figshare
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