research data . Dataset . 2016

Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine

Y. Shorning, Boris; Zabkiewicz, Joanna; McCarthy, Afshan; Pearson, Helen B.; J. Winton, Douglas; J. Sansom, Owen; Ashworth, Alan; R. Clarke, Alan;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>The Lkb1 tumour suppressor is a multitasking kinase participating in a range of physiological processes. We have determined the impact of Lkb1 deficiency on intestinal homeostasis, particularly focussing on secretory cell differentiation and development since we observe strong expression of Lkb1 in normal small intestine Paneth and goblet cells. We crossed mice bearing an <em>Lkb1</em> allele flanked with LoxP sites with those carrying a Cyp1a1-specific inducible Cre recombinase. Lkb1 was efficiently deleted from the epithelial cells of the mouse intestine after intraperitoneal injection of the inducing agent β-naphthoflavone. Bi-allelic loss of Lkb1 led...
Subjects
Medical Subject Headings: congenital, hereditary, and neonatal diseases and abnormalitiesskin and connective tissue diseases
free text keywords: Medicine, Cell Biology, Developmental Biology, lkb1, deficiency, alters, goblet, paneth, differentiation, intestine
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Dataset . 2016
Provider: figshare
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