Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines

Clemente-Vicario, Francisco; E. Alvarez, Carlos; L. Rowell, Jennie; Roy, Satavisha; A. London, Cheryl; C. Kisseberth, William; Lorch, Gwendolen;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0142007
  • Subject: Uncategorised | Heat Shock Protein 90 Inhibition | baca | Cell lines | CLAC.ResultsComparative genomic hybridization analysis | heat shock protein 90 | cell viability | lung cancer patients | Canine Lung Adenocarcinoma Cell Lines BackgroundIt | HSP 90 inhibitor | Human Genetic Relevance | lung cancer cell lines | 72 h treatment | IC 50 | Potent Antitumor Activity | sta

<div><p>Background</p><p>It has been an open question how similar human and canine lung cancers are. This has major implications in availability of human treatments for dogs and in establishing translational models to test new therapies in pet dogs. The prognosis for ca... View more
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