research data . Dataset . 2016

Molecular Evolution of the Neuropeptide S Receptor

Pitti, Thejkiran; Manoj, Narayanan;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>The neuropeptide S receptor (NPSR) is a recently deorphanized member of the G protein-coupled receptor (GPCR) superfamily and is activated by the neuropeptide S (NPS). NPSR and NPS are widely expressed in central nervous system and are known to have crucial roles in asthma pathogenesis, locomotor activity, wakefulness, anxiety and food intake. The NPS-NPSR system was previously thought to have first evolved in the tetrapods. Here we examine the origin and the molecular evolution of the NPSR using <em>in-silico</em> comparative analyses and document the molecular basis of divergence of the NPSR from its closest vertebrate paralogs. In this study, NPSR-lik...
Subjects
free text keywords: Genetics, Neuroscience, Evolutionary Biology, Biological Sciences, molecular, neuropeptide, receptor
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Dataset . 2016
Provider: figshare
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