research data . Dataset . 2016

The Moving Junction Protein RON8 Facilitates Firm Attachment and Host Cell Invasion in Toxoplasma gondii

W. Straub, Kurtis; D. Peng, Eric; E. Hajagos, Bettina; S. Tyler, Jessica; J. Bradley, Peter;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>The apicomplexan moving junction (MJ) is a highly conserved structure formed during host cell entry that anchors the invading parasite to the host cell and serves as a molecular sieve of host membrane proteins that protects the parasitophorous vacuole from host lysosomal destruction. While recent work in <em>Toxoplasma</em> and <em>Plasmodium</em> has reinforced the composition of the MJ as an important association of rhoptry neck proteins (RONs) with micronemal AMA1, little is known of the precise role of RONs in the junction or how they are targeted to the neck subcompartment. We report the first functional analysis of a MJ/RON protein by disrupting <e...
Subjects
free text keywords: Microbiology, Cancer, moving, junction, ron8, facilitates, attachment
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Dataset . 2016
Provider: figshare
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