research data . Dataset . 2016

Transplantation of Specific Human Astrocytes Promotes Functional Recovery after Spinal Cord Injury

J. A. Davies, Stephen; Shih, Chung-Hsuan; Noble, Mark; Mayer-Proschel, Margot; E. Davies, Jeannette; Proschel, Christoph;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Repairing trauma to the central nervous system by replacement of glial support cells is an increasingly attractive therapeutic strategy. We have focused on the less-studied replacement of astrocytes, the major support cell in the central nervous system, by generating astrocytes from embryonic human glial precursor cells using two different astrocyte differentiation inducing factors. The resulting astrocytes differed in expression of multiple proteins thought to either promote or inhibit central nervous system homeostasis and regeneration. When transplanted into acute transection injuries of the adult rat spinal cord, astrocytes generated by exposing huma...
Subjects
free text keywords: Neuroscience, Physiology, Developmental Biology, transplantation, astrocytes, promotes, functional, spinal
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Dataset . 2016
Provider: figshare
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