research data . Dataset . 2016

Primed Infusion with Delayed Equilibrium of Gd.DTPA for Enhanced Imaging of Small Pulmonary Metastases

Kalber, Tammy L.; E. Campbell-Washburn, Adrienne; M. Siow, Bernard; Sage, Elizabeth; N. Price, Anthony; L. Ordidge, Katherine; Walker-Samuel, Simon; M. Janes, Sam; Lythgoe, Mark F.;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><h3>Objectives</h3><p>To use primed infusions of the magnetic resonance imaging (MRI) contrast agent Gd.DTPA (Magnevist), to achieve an equilibrium between blood and tissue (eqMRI). This may increase tumor Gd concentrations as a novel cancer imaging methodology for the enhancement of small tumor nodules within the low signal-to-noise background of the lung.</p> <h3>Methods</h3><p>A primed infusion with a delay before equilibrium (eqMRI) of the Gd(III) chelator Gd.DTPA, via the intraperitoneal route, was used to evaluate gadolinium tumor enhancement as a function of a bolus injection, which is applied routinely in the clinic, compared to gadolinium maintaine...
Subjects
free text keywords: Cell Biology, Physiology, Pharmacology, Cancer, primed, infusion, delayed, equilibrium, enhanced, imaging, pulmonary, metastases
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Dataset . 2016
Provider: figshare
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