Phenotypic and Genotypic Characterization of Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Strains: Relative Roles of mprF and dlt Operons

N. Mishra, Nagendra; S. Bayer, Arnold; Weidenmaier, Christopher; Grau, Timo; Wanner, Stefanie; Stefani, Stefania; Cafiso, Viviana; Bertuccio, Taschia; Yeaman, Michael R.; C. Nast, Cynthia; Yang, Soo-Jin;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0107426
  • Subject: Biological Sciences | prototypic cationic host defense peptides | wta | dlt Operons Development | surface charge | charge repulsion mechanisms | DAP CM target | strain | mrsa | cell wall thickness | phenotype | aureus | vivo daptomycin resistance

<div><p>Development of <i>in vivo</i> daptomycin resistance (DAP-R) among <i>Staphylococcus aureus</i> clinical isolates, in association with clinical treatment failures, has become a major therapeutic problem. This issue is especially relevant to methicillin-resistant ... View more
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