research data . Dataset . 2016

Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

Amyot, Julie; Semache, Meriem; Ferdaoussi, Mourad; Fontés, Ghislaine; Poitout, Vincent;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><h3>Background</h3><p>Type 2 diabetes is characterized by pancreatic β-cell dysfunction and is associated with low-grade inflammation. Recent observations suggest that the signalling cascade activated by lipopolysaccharides (LPS) binding to Toll-Like Receptor 4 (TLR4) exerts deleterious effects on pancreatic β-cell function; however, the molecular mechanisms of these effects are incompletely understood. In this study, we tested the hypothesis that LPS alters insulin gene expression via TLR4 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in islets.</p> <h3>Methodology/Principal Findings</h3><p>A 24-h exposure of isolated human, ra...
Subjects
free text keywords: Molecular Biology, Chemistry, lipopolysaccharides, impair, insulin, islets, langerhans, toll-like, receptor-4, signalling
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Dataset . 2016
Provider: figshare
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