Interaction of Daptomycin with Lipid Bilayers: A Lipid Extracting Effect

Audiovisual UNKNOWN
Chen, Yen-Fei; Sun, Tzu-Lin; Sun, Yen; Huang, Huey W.;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/bi500779g.s003, doi: 10.1021/bi500779g.s004, doi: 10.1021/bi500779g.s002
  • Subject: Molecular Biology | cell membranes | Biotechnology | peptide | permeability | Microbiology | Lipid Extracting EffectDaptomycin | Cell Biology | Biochemistry | Pharmacology | daptomycin | giant unilamellar vesicles | fluorescence microscopy study | Biophysics | GUV lipid composition
    • FOR: 69999 Biological Sciences not elsewhere classified | 60506 Virology | 39999 Chemical Sciences not elsewhere classified
    mesheuropmc: lipids (amino acids, peptides, and proteins)

Daptomycin is the first approved member of a new structural class of antibiotics, the cyclic lipopeptides. The peptide interacts with the lipid matrix of cell membranes, inducing permeability of the membrane to ions, but its molecular mechanism has been a pu... View more
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