4‑(((4-Iodophenyl)methyl)‑4H‑1,2,4-triazol-4-ylamino)-benzonitrile: A Potential Imaging Agent for Aromatase

Dataset UNKNOWN
Song, Jin; Wu, Zehui; Wangtrakuldee, Beau; Choi, Seok Rye; Zha, Zhihao; Ploessl, Karl; Mach, Robert H; Kung, Hank;
(2016)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.jmedchem.6b00849.s004, doi: 10.1021/acs.jmedchem.6b00849.s002, doi: 10.1021/acs.jmedchem.6b00849.s003
  • Subject: Biotechnology | autoradiographic studies | imidazol -1-yl | aromatase inhibitors | stria terminalis | imaging agents | triazol | Genetics | YM | IC 50 | bed nucleus | Pharmacology | Aromatase Aromatase | aromatase imaging | brain sections | breast cancer treatment | Neuroscience | brain penetration | AI | binding affinities | rate-limiting enzyme | Log P | dose | Cell Biology | Potential Imaging Agent | Biochemistry | 0.04 nM | CYP
    • FOR: 39999 Chemical Sciences not elsewhere classified

Aromatase (CYP19) is a rate-limiting enzyme that catalyzes the biosynthesis of estrogens. Imaging agents based on aromatase inhibitors (AIs) have been developed for a PET/SPECT study. A series of compounds was synthesized based on YM511, which has previously... View more
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