Locked Conformations for Proline Pyrrolidine Ring:  Synthesis and Conformational Analysis of cis- and trans-4-tert-Butylprolines

M. P. Koskinen, Ari; Helaja, Juho; T. T. Kumpulainen, Esa; Koivisto, Jari; Mansikkamäki, Heidi; Rissanen, Kari;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/jo050838a.s001, doi: 10.1021/jo050838a.s002
  • Subject: endo envelope conformers | tert | ci | Plant Biology | Medicine | pyrrolidine ring | Computational Biology | butyl | Cell Biology | proline pyrrolidine ring | Biochemistry | 1 H NMR | favor pseudoequatorial orientation | Biophysics | tran | exo
    • FOR: 110309 Infectious Diseases | 60506 Virology | 39999 Chemical Sciences not elsewhere classified

The motional restrictions of the proline pyrrolidine ring allow this secondary amine amino acid to act as a turn inducer in many peptides and proteins. The pyrrolidine ring is known to exhibit two predominant pucker modes (i.e., C-4 (C<sup>γ</sup>) <i>exo</i> and ... View more
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