Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N‑Acylaziridines and Alkenes

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Hao, Wei; Wu, Xiangyu; Sun, James Z.; Siu, Juno C.; MacMillan, Samantha N.; Lin, Song;
(2017)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/jacs.7b06723.s003, doi: 10.1021/jacs.7b06723.s004, doi: 10.1021/jacs.7b06723.s002
  • Subject: report Ti-catalyzed | Biotechnology | harnesse | formation | approach | cleavage | Evolutionary Biology | redox-relay mechanism | alkene | Pharmacology | redox-neutral reaction | organocatalyst | Biophysics | synthesis | method | pyrrolidine | Microbiology | bond | Formal | Cycloaddition | material | Biochemistry | intermediate | Acylaziridine | bioactive compounds | Cancer | Radical Redox-Relay Catalysis
    • FOR: 80699 Information Systems not elsewhere classified | 110309 Infectious Diseases | 39999 Chemical Sciences not elsewhere classified

We report Ti-catalyzed radical formal [3+2] cycloadditions of <i>N</i>-acylaziridines and alkenes. This method provides an efficient approach to the synthesis of pyrrolidines, structural units prevalent in bioactive compounds and organocatalysts, from readil... View more
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