Iterative Assembly of Polycyclic Saturated Heterocycles from Monomeric Building Blocks

Dataset UNKNOWN
Saito, Fumito; Trapp, Nils; Bode, Jeffrey W.;
(2019)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/jacs.9b01537.s002, doi: 10.1021/jacs.9b01537.s003
  • Subject: Monomeric Building Blocks Polycyclic | DFT calculations | Biotechnology | assembly sequences | chemical reactions | morpholine-forming assembly reaction | constituent building blocks | Evolutionary Biology | iterative couplings | Pharmacology | building blocks | Biophysics | Immunology | monomer | Neuroscience | nonplanar heterocyclic arrays | target structures | heptacyclic structures | Biochemistry | bifunctional stannyl amine protocol | Iterative Assembly | silico combinations
    • FOR: 80699 Information Systems not elsewhere classified | 110309 Infectious Diseases | 39999 Chemical Sciences not elsewhere classified

Polycyclic saturated heterocycles with predictable shapes and structures are assembled by iterative couplings of bifunctional stannyl amine protocol (SnAP) reagents and a single morpholine-forming assembly reaction. Combinations of just a few monomers enable... View more
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