Tandem Synthesis of 2,3-Dihydro-4-iminoquinolines via Three-Component Alkyne-Imine Metathesis
Saito, Akio; Kasai, Jun; Konishi, Tomoyo; Hanzawa, Yuji;
- Publisher: Figshare
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- Subject: Molecular Biology | metathesi | dihydro | absence | Sociology | Physiology | amines | aldehyde | manner | tandem Synthesis | Cell Biology | Genetics | HFIP | catalyst | MetathesisIn | Biochemistry | tran
- FOR: 110309 Infectious Diseases | 39999 Chemical Sciences not elsewhere classified
In the absence of any catalysts, <i>ortho</i>-alkynylanilines react with aldehydes and amines in HFIP to form <i>trans</i>-2,3-disubstituted 2,3-dihydro-4-iminoquinolines in a complete <i>trans</i>-selective manner via the three-component alkyne-imine metathesis.
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