Quantitative Map of β-Lactone-Induced Virulence Regulation

Dataset UNKNOWN
Krysiak, Joanna; Stahl, Matthias; Vomacka, Jan; Fetzer, Christian; Lakemeyer, Markus; Fux, Anja; Sieber, Stephan A.;
(2017)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.jproteome.6b00705.s004, doi: 10.1021/acs.jproteome.6b00705.s003, doi: 10.1021/acs.jproteome.6b00705.s002, doi: 10.1021/acs.jproteome.6b00705.s001
  • Subject: Molecular Biology | MRSA | Quantitative mass-spectrometric analysis | Rot degradation | gel-free activity-based protein | virulence mechanisms | lactone-dependent phenotype | multiresistant strains | adaptor proteins | Genetics | Pharmacology | virulence regulation network | systems biology context | α- toxin | Staphylococcus aureus | proteomic comparison | β- lactone inhibition | Quantitative Map | Microbiology | feedback circuits | aureus cells | ClpP inhibition | β- lactones | proteolysis mechanism | β- Lactone-Induced Virulence Regulation β- Lactones | Cell Biology | aureus alpha-toxin production | ClpP inhibitors | Biochemistry | alpha-toxin expression | ClpX-mediated RNA | knockout studies | attenuate virulence | elucidate antivirulence pathways
    • FOR: 110309 Infectious Diseases | 60506 Virology | 39999 Chemical Sciences not elsewhere classified

β-Lactones have recently been introduced as the first selective ClpP inhibitors that attenuate virulence of both sensitive Staphylococcus aureus and multiresistant strains (MRSA). Although previous knockout studies showed that ClpP is essential for S. aureus... View more
Share - Bookmark

  • Download from
    figshare via figshare (Dataset, 2017)
  • Cite this research data