Insights into Nucleotide Recognition by Cell Division Protein FtsZ from a mant-GTP Competition Assay and Molecular Dynamics

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Schaffner-Barbero, Claudia; Gil-Redondo, Rubén; Ruiz-Avila, Laura B.; Huecas, Sonia; Läppchen, Tilman; Blaauwen, Tanneke den; Diaz, J. Fernando; Morreale, Antonio; Andreu, Jose M.;
(2010)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/bi101577p.s007, doi: 10.1021/bi101577p.s006, doi: 10.1021/bi101577p.s005, doi: 10.1021/bi101577p.s004, doi: 10.1021/bi101577p.s003, doi: 10.1021/bi101577p.s002
  • Subject: Biotechnology | Molecular DynamicsEssential cell division protein FtsZ forms | binding | 10 nM range | crystal structures | fluorescence anisotropy change | FtsZ monomers bind GTP | Pharmacology | Biophysics | nucleotide site | Microbiology | eukaryotic tubulin assembly | FtsZ monomers | GDP | GTP phosphate mimetics | Biochemistry | Cell Division Protein FtsZ | Cancer
    • FOR: 110309 Infectious Diseases | 60506 Virology | 39999 Chemical Sciences not elsewhere classified
    mesheuropmc: bacteria | biological phenomena, cell phenomena, and immunity | macromolecular substances | physiological processes

Essential cell division protein FtsZ forms the bacterial cytokinetic ring and is a target for new antibiotics. FtsZ monomers bind GTP and assemble into filaments. Hydrolysis to GDP at the association interface between monomers leads to filament disassembly. We have deve... View more
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