Efficient Asymmetric Synthesis of P‑Chiral Phosphine Oxides via Properly Designed and Activated Benzoxazaphosphinine-2-oxide Agents

Han, Zhengxu S.; Goyal, Navneet; Herbage, Melissa A.; Sieber, Joshua D.; Qu, Bo; Xu, Yibo; Li, Zhibin,; Reeves, Jonathan T.; Desrosiers, Jean-Nicolas; Ma, Shengli; Grinberg, Nelu; Lee, Heewon; P. R. Mangunuru, Hari; Zhang, Yongda; Krishnamurthy, Dhileep; Lu, Bruce Z.; Song, Jinhua J.; Wang, Guijun; Senanayake, Chris H.;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/ja312352p.s004, doi: 10.1021/ja312352p.s005, doi: 10.1021/ja312352p.s001, doi: 10.1021/ja312352p.s002, doi: 10.1021/ja312352p.s003
  • Subject: Molecular Biology | agent | reactivity | diastereoselective method | sterically | phosphinyl | AgentsA | cleavage | Genetics | Evolutionary Biology | phosphine | Efficient Asymmetric Synthesis | Benzoxazaphosphinine | synthesis | chiral | Developmental Biology | Microbiology | Medicine | sequential nucleophilic substitution | bond | reactivitie | transfer | oxide | nucleophile | Biochemistry | Activated
    • FOR: 59999 Environmental Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

A general, efficient, and highly diastereoselective method for the synthesis of structurally and sterically diverse <i>P</i>-chiral phosphine oxides was developed. The method relies on sequential nucleophilic substitution on the versatile chiral phosphinyl tran... View more
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