Effect of Cobratoxin Binding on the Normal Mode Vibration within Acetylcholine Binding Protein

Audiovisual UNKNOWN
Bertaccini, Edward J.; Lindahl, Erik; Sixma, Titia; Trudell, James R.;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/ci700456s.s004, doi: 10.1021/ci700456s.s003, doi: 10.1021/ci700456s.s002, doi: 10.1021/ci700456s.s001
  • Subject: Molecular Biology | Biotechnology | acetylcholine binding protein | protein cobratoxin ligands | LGIC | receptor dynamics | Computational Biology | Normal Mode Vibration | Acetylcholine Binding ProteinRecent crystal structures | AChBP | Cell Biology | Biochemistry | Pharmacology | ion channel motion | alteration | Biophysics | ligand binding
    • FOR: 29999 Physical Sciences not elsewhere classified | 69999 Biological Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

Recent crystal structures of the acetylcholine binding protein (AChBP) have revealed surprisingly small structural alterations upon ligand binding. Here we investigate the extent to which ligand binding may affect receptor dynamics. AChBP is a homologue of the extracell... View more
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