Integrating Enzymatic Self-Assembly and Mitochondria Targeting for Selectively Killing Cancer Cells without Acquired Drug Resistance

Audiovisual UNKNOWN
Wang, Huaimin; Feng, Zhaoqianqi; Wang, Youzhi; Zhou, Rong; Yang, Zhimou; Xu, Bing;
(2016)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/jacs.6b09783.s002, doi: 10.1021/jacs.6b09783.s003
  • Subject: 1 P | Biotechnology | Selectively Killing Cancer Cells | cancer cells | Saos 2 cells | Space Science | Genetics | Pharmacology | assembly | Biophysics | Immunology | EISA | release cytochrome c | ALP | Neuroscience | Microbiology | form nanoscale assemblies | Cell Biology | TPP | Biochemistry | Cancer | Drug Resistance Targeting organelles | drug resistance
    • FOR: 60506 Virology | 39999 Chemical Sciences not elsewhere classified

Targeting organelles by modulating the redox potential of mitochondria is a promising approach to kill cancer cells that minimizes acquired drug resistance. However, it lacks selectivity because mitochondria perform essential functions for (almost) all cells... View more
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