Palladium-Catalyzed C–N Bond Cleavage of 2H‑Azirines for the Synthesis of Functionalized α‑Amido Ketones

Dataset UNKNOWN
Xu, Fen; Si, Xiao-Ju; Song, Yuan-Yuan; Wang, Xing-Dong; Liu, Chun-Sen; Geng, Peng-Fei; Du, Miao;
(2019)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.joc.8b03193.s002, doi: 10.1021/acs.joc.8b03193.s003, doi: 10.1021/acs.joc.8b03193.s004, doi: 10.1021/acs.joc.8b03193.s005
  • Subject: Molecular Biology | Amido | Functionalized | Pd-catalyzed ring-opening reaction | Ketone | Space Science | cleavage | diaryl | Azirine | carboxylic acids | single-bond | α- amido ketone derivatives | construction | nucleophilic | Biophysics | Immunology | tolerance | efficiency | method | -2 | Developmental Biology | Microbiology | Medicine | Bond | Palladium-Catalyzed | Biochemistry | Synthesi | rearrangement
    • FOR: 59999 Environmental Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

A Pd-catalyzed ring-opening reaction of 2<i>H</i>-azirines with carboxylic acids was developed. This reaction undergoes nucleophilic addition between 2,3-diaryl-2<i>H</i>-azirines and carboxylic acids followed by C–N single-bond cleavage and a subsequent ... View more
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