Dearomatization Approach to 2‑Trifluoromethylated Benzofuran and Dihydrobenzofuran Products

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Smith, David T.; Vitaku, Edon; Njardarson, Jon T.;
(2017)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.orglett.7b01479.s001, doi: 10.1021/acs.orglett.7b01479.s002, doi: 10.1021/acs.orglett.7b01479.s003
  • Subject: hfacac | Biotechnology | dearomatization | 2- trifluoromethyl group | dihydrobenzofuran product | reagent addition order | Ecology | Genetics | Evolutionary Biology | hexafluoro | form hydrates | 3- | Biophysics | substituent | Trifluoromethylated | hypervalent iodine | benzofuran products | Benzofuran | Dearomatization Approach | Developmental Biology | ortho | Dihydrobenzofuran Products | bond | Computational Biology | phenoxonium | Biochemistry | Cancer | choice | replacement
    • FOR: 110309 Infectious Diseases | 39999 Chemical Sciences not elsewhere classified

A mild dearomatization enabled <i>ortho</i>-selective replacement of an aromatic C–H bond with a hexafluoro­acetylacetone (hfacac) substituent has been developed. This reaction is dependent on a hypervalent iodine generated phenoxonium intermediate, a critical ... View more
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